Dr. Dawn Merton Boothe
Auburn University

Study Start Date: 03/01/2007
Study End Date: Open

Evidence of Effective Drug Delivery using Transdermal Gel Delivery Systems in Cats.

A number of studies by other investigators have demonstrated poorly predictable drug concentrations following single doses of transdermal administration. However, drug delivery may be more predictably effective with multiple dosing, once steady-state has been achieved and skin permeability has been altered (as has been shown for methimazole). Because of factors that complicate transdermal drug delivery, efficacy should be demonstrated for each drug delivered by this method, in the target species. The simplest way to prove effective delivery of a drug in a patient is by detecting drug concentrations in patients receiving the gels therapeutically, along with measuring the drug in the preparation itself (to assure appropriate potency of the compounded preparation)...READ MORE